NYCC Neuro I Practice Test

In the sympathetic system, one preganglionic neuron typically connects to many postganglionic neurons, creating broad, coordinated activation across multiple organs. The usual pattern is that a single preganglionic fiber branches to innervate roughly ten postganglionic fibers. This divergence lets a single signal produce a widespread fight-or-flight response, affecting heart rate, vascular tone, glandular activity, pupil dilation, and more.

To understand why, remember where these cells are and how they connect: preganglionic neurons reside in the thoracic and upper lumbar regions, their axons reach the sympathetic ganglia via white rami, then they synapse onto postganglionic neurons whose fibers travel to target tissues. The high degree of postganglionic innervation per preganglionic neuron is what enables the rapid, coordinated bodily-wide response characteristic of sympathetic activation.